Serena, Venus Williams cruise into second round after easy victories

The Australian suffered 6-4 6-3 4-6 7-6 defeat against the unseeded Bosnian in New York

Williams drew the tough Ekaterina Makarova in the first round, but she looked like her usual self, winning in straight sets, 6-3, 6-3.

She was not the only seed to fall on Tuesday.

Williams has won the US Open six times in her career so far and will be hoping to land her seventh at the end of this year's tournament.

He'd lost five straight Grand Slam matches dating to the 2013 U.S. Open before Tuesday.

Djokovic, who is now ranked No. 1 in men's singles, will compete in the U.S. Open as the top-seeded male player. The sixth-seeded American opens her tournament against 93rd-ranked Kateryna Kozlova on Tuesday.

The first hurdle in Williams' path is a tall one: 29-year-old left-hander Ekaterina Makarova. The 2008 French Open champion finished with seven double-faults and 41 unforced errors.

Ukrainian 19th seed Vesnina went down 6-7 (4-7) 6-4 6-3 to Anett Kontaveit, 20th seed Bertens crashed to a 6-3 2-6 6-4 defeat at the hands of Ana Konjuh, while Wang Qiang dispatched 23rd seed Daria Kasatkina 6-4 2-6 6-2.

FLIPPING OUT: Venus Williams hasn't played a singles match since an early exit in Rio, either - though she did wind up winning silver in mixed doubles. An injury hampered her preparation, and she served miserably in the match.

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"I got off to a fast start, because I knew she was a really tough opponent", Serena said of the former world No. 8 and Rio Olympics gold medal victor in doubles.

Williams went past the previous best of major appearances of 71 she shared with fellow American Amy Frazier.

The Romanian was ahead 6-0, 5-0 with countrywoman Nadia Comaneci cheering her on.

Markarova beat her in a big spot - the fourth round of the 2012 Australian Open - and Serena was engaged from the beginning. Comaneci was the first gymnast to score a ideal 10 at the 1976 Montreal Olympics. She's gotten to the semifinals.

The two-time defending Wimbledon champion likes to dictate play from the baseline, and the duo could engage in long rallies which Williams usually comes out on top, and occasionally throws in a drop shot to confuse her opponents.

Fourth seed Agnieszka Radwanska of Poland, trying to make it to the quarter-finals in NY for the first time, breezed past United States qualifier Jessica Pegula 6-1, 6-1 and fifth-seeded Romanian Simona Halep also eased through with a 6-0, 6-2 victory over Belgian Kirsten Flipkens.

Halep, a victor of three WTA Tour events this season, including a hardcourt event in Montreal, carried her superb form into Flushing Meadows as she needed just one hour on a sun-splashed but nearly vacant Arthur Ashe Stadium court to dismiss the 56th-ranked Belgian. In her last outing, a third-round loss to Elina Svitolina in the Olympics, her serve deserted her much as it did against Makarova in Melbourne 4 1/2 years ago.

No. 2 Andy Murray vs. Lukas Rosol No. 3 Stan Wawrinka def. Fernando Verdasco, 7-6 (4), 6-4, 6-4 No. 6 Kei Nishikori def. Benjamin Becker, 6-1, 6-1, 3-6, 6-3 No. 8 Dominic Thiem vs. John Millman No. 11 David Ferrer def. Alexandr Dolgopolov, 6-5 (ret.) Jared Donaldson def. "He's a tough, tough opponent, a big, strong guy".