The Britain-based Syrian Observatory for Human Rights said Syrian government warplanes and artillery struck more than 20 neighborhoods in east Aleppo killing six people.
Injured boys react at a field hospital after airstrikes on the rebel held areas of Aleppo, Syria November 18, 2016.
A series of airstrikes by Syrian regime and Russian forces have closed down all remaining hospitals in the eastern area of the rebel-held city Aleppo, Syria.
"The intentional destruction of infrastructure for survival has made the besieged steadfast people, including children, elderly and men and women, without medical facilities to treat them", the statement said.
'The bombing of the last functioning hospital in Aleppo is part of a systematic campaign to remove even the most basic of services left in the city, ' Patel said.
The U.S. on Saturday said the attacks on medical facilities and aid workers should end and demanded Russian Federation do more to ebb the violence.
Staffan De Mistura, the special envoy of the United Nations secretary general, is likely to meet Syrian Foreign Minister Walid al-Moalem in Damascus on Sunday after recent talks in Turkey and Iran, another diplomat said.
Both countries have denied opposition accusations they have deliberately targeted hospitals and other civilian infrastructure during the war, which began in 2011 and was joined by Russia's air force in September 2015.The war pits President Bashar al-Assad backed by Russia, Iran and Shiite militias against a medley of Sunni rebels including groups supported by the United States, Turkey and Gulf monarchies, as well as militant groups.
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The charity Doctors Without Borders said in a message there had been more than 30 hits on hospitals in eastern Aleppo since early July.
"It is a catastrophic day in besieged Aleppo with unprecedented bombardment with every type of weapon", a member of the White Helmets rescue group said in a video on the organization's Facebook page.
Health and rescue workers have previously been able to bring hospitals put out of service by air strikes back into operation but a lack of supplies is making that harder.
The news comes amid reports that intense government air strikes and artillery fire on the rebel-held side of Aleppo city have targeted multiple hospitals and forced schools to close. Rebel shelling, meanwhile, killed dozens of people in government-held western Aleppo during a failed counter attack.
"It is imperative all parties agree to the plan and allow us to secure immediate, safe and unimpeded access to provide relief to those most in need in east Aleppo, but equally in all other parts of Syria where there are people in need".
Syria's grinding five-year conflict has devastated the city, divided between government-controlled areas in the west and rebel positions in the east.
The U.N. humanitarian adviser said the besieged population of eastern Aleppo faced a "very bleak moment" with no food or medical supplies, winter approaching, and an increasingly fierce attack by Syrian and allied forces.