She hailed the win as her second of the season, with the first being her actual return to the court in Paris.
If Novak Djokovic was hoping to take a little pressure and attention off himself after some rough results, he might very well have found the ideal way to do that by adding Andre Agassi as a coaching consultant of sorts for the French Open.
Djokovic went up 4-1 in the second set but failed to convert eight set points when at 5-3.
Two of the four seeded USA women in the French Open have lost their first-round matches. In the last game, Kerber held seven break points but Makarova fought off each one despite, she said, "fighting with my emotion".
Former No. 1 Caroline Wozniacki, the 11th seed who missed the event a year ago, also got through the first round, beating Australia's Jaimee Fourlis 6-4, 3-6, 6-2.
Kvitova, who won the Wimbledon title in 2011 and 2014 and climbed as high as No. 2 in the WTA rankings, was not allowed to speak about the attack itself because a police investigation is still ongoing.
Garbine Muguruza survived a tricky first hurdle to open her French Open title defence with a 6-2, 6-4 victory against the 2010 victor Francesca Schiavone. And after that I make the break straight away and then finished a close set, and it was a little bit less hard.
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Bowing out at the hands of 40th-ranked Russian Ekaterina Makarova, the German became the first top seeded woman to lose in the opening round of the French Open since the sport turned professional in 1968. Cornet won her first-round match in 2005 before losing to Amelie Mauresmo in the second. "I stayed in life and I have all my fingers".
The 30-year-old Spaniard, who is seeking an unprecedented 10th title at Roland Garros, beat Benoit Paire 6-1, 6-4, 6-1 in the opening round.
The tournament has a wide-open feel with American Serena Williams sitting out the rest of the season due to her pregnancy.
With Agassi, sporting a black t-shirt and sunglasses, quietly sitting in the stands along with the Serb's entourage, it was a similar story early in the second set with the world number two returning everything Granollers tried to throw at him.
Asked how her hand felt, she replied: "I didn't feel any differences, which is nice".
With Granollers' mistakes accumulating, Djokovic needed just one match point to close out the match.
Djokovic, with new coach Andre Agassi watching on from the player's box, was the first of the two superstars to take to court on Monday, with the first match at the Philippe-Chatrier ending quickly and giving the Serbian an opportunity to make an early statement at Roland Garros.
Garbine Muguruza is the reigning women's French Open champion.