"That's how back problems are", Klopp said on November 3.
Nathaniel Clyne has been dealt another setback at his continues to recover from a long-standing back injury, with the Liverpool midfielder set to miss another three months after undergoing corrective surgery on Monday.
Clyne will hope to regain fitness and form by the time the summer comes around, with him undoubtedly harbouring ambitions of featuring in the World Cup in Russian Federation with Gareth Southgate'sEngland squad.
The decision was then taken for Clyne to have surgery and he underwent the procedure on Monday.
Joe Gomez and Trent Alexander-Arnold have been deployed at right-back by Klopp in his absence while Tottenham's Kieran Trippier has been favoured by Gareth Southgate in the England set-up.
Giants standing by McAdoo - for now
We need to go take a long hard look at the tap, at the game, make sure we get everything corrected and be honest with each other. While I guess there's still a possibility, head coach Kyle Shanahan said that he doesn't have a plan yet for Garoppolo to start.
It now remains to be seen if Liverpool dip into the market in the January transfer window to get a replacement for Clyne.
The England defender has been out since Liverpool's pre-season game against Tranmere Rovers in July.
Mané, meanwhile, has been released early from worldwide duty after picking up the problem during Senegal's 2-0 World Cup qualifying win over South Africa last Friday.
"Obviously it is a concern that the hamstring injury is again on the agenda and it will be critical for us to monitor and manage that in the coming days", Klopp told liverpoolfc.com.
"In his case because it was a little sign again from the back, we took him out and it's a few steps back again". It is pretty certain he'll not be available for the majority of the Champions League group matches.