This'll be the first meeting between the Saints and Fulham in almost four years since the visitors last made the trip to west London; a team which consisted of the likes of Luke Shaw and Victor Wanyama was able to satisfactory overcome the Cottagers with a 3-0 result in the Premier League back in February 2014 - Adam Lallana, Rickie Lambert and Jay Rodriquez with the goals that day. There will also be a north-east derby with Middlesbrough taking on their Championship rivals Sunderland while Manchester City will welcome Burnley to the Etihad Stadium.
This is the stage at which all Premier League and Championship teams join the tournament, plus the teams that won previous qualifying rounds.
Giroud urged to find playing solution
The 31-year-old marksman led the line for France in the last major global tournament, Euro 2016. Giroud has not started a single league game this term , only featuring as a substitute.