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Global Positioning System reverse type 2 diabetes with weight loss program

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The vast majority of diabetes cases are Type 2 strongly linked to lifestyle such as poor diet excess weight and inactivity and genetics

Nearly a quarter of the 149 patients in the weight management group achieved weight loss of 15 kg or more at 12 months, sufficient to achieve remission of diabetes in 90% of cases - defined as HbA1c 48mmol/mol.

The trial was supervised by professors Mike Lean and Roy Taylor of the University of Glasgow and the University of Newcastle respectively.

An extreme low-calorie diet that leads to an average weight loss of 10 kilograms can reverse type 2 diabetes, even six years into the disease, a Lancet study shows.

Whether it be genetics or just every day choices, Boyd said Type 2 diabetes is a problem that won't be going away anytime soon. Over half (57 per cent) of those who lost 10 to 15kg achieved remission, along with a third (34 per cent) of those who lost five to 10kg.

'But our results should pave the way for this type of intervention to be considered in the routine care of patients with type 2 diabetes who wish to attain diabetes remission'.

Prof. Taylor says that significant weight loss reduces the amount of fat in the liver and pancreas so that they can start working normally again. Remission was defined as having blood glucose levels (HbA1c) of less than 6.5% per cent (48mmol/mol) at 12 months, with at least two months without any type 2 diabetes medications.

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In the United States, about 30 million people have type 2 diabetes.

The researchers said the high rates of reversal showed that weight management should take priority over anti-diabetes drugs as the first-line treatment for people with type 2 diabetes. According to data from the U.S. Centers for Disease Control and Prevention (CDC) reports, type 2 diabetes accounts for around 90 to 95 percent of cases in adults. Diet and lifestyle are touched upon but diabetes remission by cutting calories is rarely discussed. One that doesn't really on expensive medications or invasive surgery, but instead, on improved diet and lifestyle - which could also be beneficial in managing and preventing a number of other chronic conditions which are affected by weight. "The big challenge is long-term avoidance of weight re-gain".

The earlier research came from the ongoing experimental study, known as DiRECT (Diabetes Remission Clinical Trial) that aims to discover an effective way to keep the type 2 diabetes at remission for long-term.

"It's very important that anyone living with Type 2 diabetes considering losing weight in this way seeks support and advice from a healthcare professional".

Dr Elizabeth Robertson, director of research at Diabetes UK, which has committed more than £32.8m to the DiRECT study, welcomed the findings.

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