Chelsea, meanwhile, had to settle for second place in Group C following their 1-1 draw with Atletico Madrid at Stamford Bridge on Tuesday night.
Another former Jose team that United could face off against in the Champions League round of 16 stages, a clash against Porto will be the Red Devils' best possible opportunity to progress to the next stages.
If Liverpool do secure top spot that makes things even trickier for Chelsea.
When is the Champions League last 16 draw?
However, with the competition now taking a break until February, domestic matters are at the forefront of Azpilicueta's mind, with Chelsea currently 11 points behind Manchester City and three behind Manchester United in third place in the Premier League, while they also face Bournemouth in the EFL Cup quarter-finals this month before they enter the FA Cup in January.
As such, the Blues will now get a more hard draw in the next round of the competition.
While North London rivals Arsenal have faced a joyless slog through Europa League Group H, Spurs have had a Champions League group stage to remember.
With Premier League clubs struggling, La Liga teams have unquestionably taken a stranglehold of the competition, with the past four winners of the competition all hailing from Spain's top flight - Barcelona lifted the trophy in 2015 while Real Madrid won it in 2014, 2016 and 2017.
A tie against either Sevilla or Shakhtar Donetsk might not exactly be the worst either, but could prove to be a potential banana skin for the twenty-time English champions. Furthermore, only four times in the last 14 years has a full complement of La Liga teams reached the last 16.
With Liverpool's 7-0 destruction of Spartak Moscow on Wednesday, the English Premier League officially placed five clubs into the Champions League Round of 16 in what is a remarkable turnaround for the league.