Prior to the defeat, Spurs manager Mauricio Pochettino admitted the goal mockery had affected his star striker, telling The Guardian: "It's normal that he was a little bit disappointed because Harry and all our players have Twitter, Instagram and all those things, and while Tottenham fans will have supported him, fans of other clubs will have killed him".
The 24-year-old look extremely isolated at times as City dominated the ball, and had no meaningful chances in the game as the visitors took all three points.
Roma were drawn against Liverpool in the semi-finals of the Champions League this afternoon.
Spurs needed somebody to step up and make something happen.
"We are very happy, we wanted to win the league but it has been a hard season, there has been a lot of improvements in other teams. I don't care about the rest".
Sadio Mane opened the scoring in the first half before the Egypt worldwide netted his 30th goal in the Premier League with a superb header over Asmir Begovic.
Mohamed Salah is in the middle of the most prolific scoring season by a Liverpool player since the heyday of Ian Rush.
Harry Kane was awarded a goal in last weekend's win at Stoke City. "I think he is going to learn a lot from this you know".
"It's also very close, it's just seven goals but let's see", he added. "But playing with him every day in training I can see how hard he works, he wants goals, he's a striker, every striker wants goals, so he has just got to ignore it and focus on himself which I am sure he will do, he is an unbelievable player and he is a great person as well".
"I will try my best to score again and help the team".